Papaya Enzyme: Definition, Benefits & Risks
Key Takeaways
- Papaya enzyme, also known as papain, helps break down proteins, making it easier to digest food and absorb nutrients. This can reduce bloating, constipation, and acid reflux. Want to know more about papaya enzyme benefits? Read below!
- Papaya enzyme has anti-inflammatory properties that can help with joint pain, recovery from injuries, or dental procedures. Read on to see more scientific evidence supporting how beneficial papain is.
- While papaya enzyme supplements offer benefits, they lack the fiber, vitamins, and minerals found in whole papaya. However, balancing dosage is necessary. Discover in this article the good amount of papain intake.

Papaya enzyme
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What Is Papain?
Papain is a proteolytic enzyme found in the white fluid (latex) of unripe papayas. Its main function is breaking down proteins, which helps your body digest food and absorb nutrients better.
Besides supporting body digestion, this papaya enzyme has many other uses. It’s often used as a meat tenderizer in cooking and in lab settings for testing. It also plays a role in healthcare, helping with wound healing and with dental issues like decay.
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Potential Papaya Enzyme Benefits
1. May Ease a Sore Throat
Papaya enzyme might help reduce soreness, swelling, and redness in the throat. In a study, lozenges containing papain relieved sore throat symptoms better than a placebo, though it’s unclear if papain alone was responsible.
If you want to try it, chew a lozenge containing papain at the first sign of discomfort, following dosage instructions.
2. May Reduce Pain and Inflammation
Papaya enzyme has anti-inflammatory properties that may help alleviate pain from joint issues, dental surgery, or conditions like fibromyalgia.
While more research on humans is needed, papain shows promise in reducing swelling and discomfort. Talk to your doctor before using it, especially if you take medications.
3. May Aid Digestion
Papain can help ease digestive issues like bloating, constipation, and acid reflux by improving protein breakdown. Studies suggest that eating papaya or using papaya extract can support gut health and reduce GERD symptoms.
You can include papaya in your diet or use supplements like papaya extract for digestive support.

Papaya enzyme will ease your digestive. Source: Harvard Health
4. May Help Heal Wounds
Papaya enzyme has been shown to promote wound healing by reducing dead tissue and preventing infections. Studies on animals and humans have found that papain in dressings or creams can help with ulcers and other wounds.
However, some people may have allergic reactions, so consult your doctor before use.
5. May Help Prevent Obesity
Animal studies suggest papain might slow weight gain by reducing body fat accumulation. While more human research is needed, adding papaya to your diet is a natural way to incorporate this enzyme.
Eating ripe papaya can provide papain naturally without needing supplements.
The Risks And Side Effects Of Papain
While it’s widely used for its potential health benefits, such as aiding digestion, there are some risks and papain side effects you should be aware of when using papain supplements or consuming it in high doses.
- Irritation and Damage: High doses of papain may irritate the throat or stomach and, in severe cases, even damage the esophagus.
- Allergic Reactions: If you're allergic to latex or papaya, papaya enzymes can trigger allergic reactions, leading to potential symptoms like rashes, blisters, or skin irritation, especially if used topically.
- Blood Sugar Effects: One of the risky papain side effects is lower blood sugar levels, especially for those who have diabetes, hypoglycemia, or are taking medications or natural remedies that also lower blood sugar.
- Increased Bleeding Risk: Papaya enzyme may thin the blood and increase the risk of bleeding. Avoid it if you take blood thinners, have a blood clotting disorder, or are preparing for surgery (stop use at least two weeks prior).
- Pregnancy and Birth Risks: Papain, found in unripe papaya, may pose risks for pregnant or nursing individuals. Consuming it in large amounts could potentially lead to fetal poisoning or birth defects.

Papain can be risky during pregnancy
Are Papaya Supplements As Beneficial As Papaya Fruit?
Papaya supplements, which often contain concentrated amounts of papaya enzyme (papain), can offer certain benefits, like supporting digestion.
These papaya enzyme benefits might make them appealing if you’re looking for quick digestive relief. However, they don’t measure up to the whole fruit in terms of overall nutrition.
Here’s why:
- Nutritional Content: While papaya supplements focus on the enzyme papain, they lack the fiber, vitamins (like Vitamin C), and minerals (like potassium) found in whole papaya fruit. Eating the fruit provides a more balanced and nutrient-dense option.
- Risk of Overuse: It’s easy to overdo it with supplements, and too much papain may harm your esophagus or cause other side effects. Whole papaya is less likely to lead to such risks when consumed in moderation.
- Supplement Quality Concerns: Supplements aren’t FDA-regulated, meaning what’s on the label might not always be accurate. To ensure safety, choose high-quality brands that are third-party tested by organizations like USP or NSF International.
- The Natural Advantage: Whole papaya doesn’t just provide papain—it’s a rich source of antioxidants and dietary fiber, which support overall gut health and beyond. Supplements can’t replicate this natural package.
Recommended Dosage And Usage Of Papain Enzymes
When it comes to using papaya enzyme (papain), it’s important to follow guidelines to maximize papaya enzyme benefits while minimizing risks and papain side effects.
- Oral Use: Papain has been commonly taken in doses of 1200 mg daily for up to 10 weeks when combined with other ingredients. This is often for digestive support or other specific health concerns.
Topical Use: Papain is sometimes applied to the skin in solution form, but this should only be done under professional guidance to avoid irritation or allergic reactions.
Papain Enzymes vs. Other Digestive Aids
When it comes to supporting digestive health, papain enzymes offer several advantages over traditional digestive aids, such as antacids, proton pump inhibitors (PPIs), and other enzyme supplements.
Unlike many synthetic digestive aids, papain enzymes are a natural and plant-based solution. They are derived directly from the papaya fruit, which has been used for centuries in traditional medicine for its digestive properties. This natural origin means that papain enzymes are generally well-tolerated by the body and pose a lower risk of adverse side effects compared to some pharmaceutical options.
Moreover, papain enzymes are not limited to just aiding in protein digestion. As mentioned earlier, they have the ability to enhance the breakdown of other macronutrients, such as carbohydrates and fats, as well as dietary fiber. This versatility sets papain enzymes apart from more specialized digestive aids, which may only target specific aspects of the digestive process.
Unlike antacids or PPIs, which primarily focus on reducing stomach acid production, papain enzymes work to improve the overall efficiency of the digestive system. By facilitating the breakdown and absorption of nutrients, papain enzymes can help address the root causes of digestive issues, rather than just temporarily masking the symptoms.
Frequently Asked Questions
1. Can I take papaya enzymes every day
Yes, You can take papaya enzymes daily if used as directed and in recommended doses. They may support digestion and offer benefits. However, avoid overuse, as it can cause papain side effects like irritation or allergic reactions. Always consult a healthcare provider to ensure daily use is safe and suitable for your needs.
2. Does papaya enzyme make you poop?
Yes, papaya enzyme can help you poop! It contains papain, which aids digestion by breaking down proteins. This can improve gut health and ease constipation. However, it’s not a strong laxative, so its effects are gentle. For consistent results, eat whole papaya for added fiber and nutrients.