
Are pre pro and postbiotics really the secret to better health? The human body is full of bacteria, especially in the gut. Some of these bacteria are harmful, but many are actually good and help keep the body working properly. This is where pre pro and postbiotics come into play. These three are often mentioned in discussions about gut health, but not everyone knows what they are or how they work together.
What Are Postbiotics, Really?

There’s a lot of confusion around the term “postbiotics.” Some people think it’s just another version of probiotics. But here’s a simple way to understand it: postbiotics are the useful stuff your gut bacteria leave behind after digesting food, particularly prebiotics.
Pre pro and postbiotics work as a team. Prebiotics are fibers and compounds that feed the good bacteria in the gut. Probiotics are the live bacteria themselves. Postbiotics? They’re what’s left after the bacteria finish munching on prebiotics.
These leftovers include short-chain fatty acids (SCFAs), vitamins, amino acids, and other powerful compounds that help regulate everything from inflammation to the immune system.
How Are Postbiotics Made?
Think of pre pro and postbiotics like this: Prebiotics go in, probiotics do their thing, and postbiotics come out. This process happens naturally in the gut every day. When probiotics digest fibers like inulin or resistant starch, they produce substances like butyrate, acetate, and propionate or all types of SCFAs.
Other postbiotics include:
- Enzymes
- Bacterial cell wall fragments
- Exopolysaccharides
- Lipopolysaccharides
- Vitamins B and K
- Antimicrobial peptides
So even though postbiotics are technically bacterial “waste,” they’re anything but useless.
Why Not Just Take Probiotics?

Here’s a good question: If probiotics create postbiotics, why not just take probiotics and be done with it? The answer lies in how different bodies react.
Some people don’t tolerate probiotics well. They might cause bloating, gas, or discomfort. Others may have gut conditions where live bacteria don’t thrive or cause complications. This is where postbiotics supplements come into play. Since postbiotics are not live organisms, they’re generally more stable and easier on the digestive system.
Postbiotics supplements give the benefits of probiotics without the risk of side effects from live bacteria. Pretty neat, right?
4 Health Benefits of Postbiotics
The benefits of postbiotics supplements are getting a lot of attention, and for good reason. These compounds seem to support the body in more ways than one might expect.
Immune System Support
Certain postbiotics, like butyrate, can encourage the production of T-cells (immune cells that help regulate the body’s defenses). They can also boost the production of cytokines, which are messengers that reduce inflammation and help the immune system respond properly.
In fact, research has shown that postbiotics supplements may help reduce the risk of respiratory infections. Studies on older adults even showed that regular supplementation reduced the chances of catching the common cold.
Better Digestion
Got a sensitive stomach? Postbiotics can help ease symptoms like bloating, diarrhea, and cramping especially for people with IBS or IBD. Short-chain fatty acids like butyrate help maintain a strong intestinal barrier and reduce gut inflammation. This makes digestion smoother and less irritating.
Some people with Crohn’s disease or ulcerative colitis produce less butyrate naturally. Taking postbiotics supplements might offer some much-needed relief.
Fighting Diarrhea
Postbiotics have shown promise in fighting both chronic and antibiotic-related diarrhea. For instance, children and adults who took postbiotics supplements during or after antibiotics experienced fewer gut issues.
Studies also suggest that postbiotics may help reduce the frequency and duration of diarrhea caused by infections.
Other Emerging Benefits
Science is still uncovering all the ways postbiotics can help. Some early findings suggest they may:
- Support healthy blood sugar levels
- Aid in weight management
- Improve skin issues like eczema
- Lower cholesterol and blood pressure
- Even show anti-cancer potential (though it’s early days for that)
Natural Sources of Postbiotics

You don’t have to rely only on postbiotics supplements to get the benefits. The body can make them naturally with the right foods.
Here’s what helps:
- Fermented foods like yogurt, kefir, kimchi, tempeh
- Fiber-rich foods like garlic, onions, leeks, oats, and bananas
These foods support pre pro and postbiotics interactions in the gut. Eating a mix of fermented and high-fiber foods creates the ideal environment for beneficial bacteria to thrive and produce helpful postbiotics.
What’s the Difference Between Probiotics and Postbiotics?
Let’s clear up the confusion once and for all:
Feature | Probiotics | Postbiotics |
What They Are | Live bacteria and yeasts | Byproducts made by those live microbes |
Function | Balance the gut microbiome | Support immune and gut health |
Found In | Yogurt, kefir, sauerkraut | Supplements, bacterial metabolites |
Stability | Sensitive to heat and moisture | Stable, shelf-safe |
Who Benefits | Most people (with some exceptions) | Almost everyone, especially sensitive guts |
This table makes it easier to understand why someone might choose postbiotics supplements over probiotics or better yet, use them together.
Can You Take All Pre Pro and Postbiotics Together?
Absolutely. In fact, combining pre pro and postbiotics might be the smartest approach. Prebiotics feed the probiotics, and the probiotics produce the postbiotics. It’s a perfect cycle.
Some people take all three as separate supplements, while others focus on food sources. Either way, the key is balance.
Are Postbiotics Safe?
Generally, yes. Because they’re not live organisms, postbiotics supplements don’t carry the risks associated with live bacteria, such as infections in immune-compromised people.
However, quality matters. It’s always best to choose trusted brands that are backed by science. And anyone with a medical condition should check with a healthcare provider before starting something new.
How to Choose Postbiotic Supplements
This part matters more than most people think. Not all postbiotics supplements are created equal. Look for products that:
- Clearly list the types of postbiotics included
- Are backed by clinical research
- Avoid unnecessary fillers or additives
Some trusted postbiotic ingredients to look for:
- Butyrate
- Bacterial lysates
- Cell wall fragments
- Supernatant (the liquid portion left after bacteria are removed)
The Takeaway
So, are pre pro and postbiotics just hype? Or are they a new frontier in wellness? The research is pointing more and more toward the latter. These three players work best as a team, and understanding each one’s role can lead to better health choices.
Postbiotics supplements are an exciting addition to the gut health toolbox. They offer the benefits of probiotics without the risks and may even do more in certain cases. Whether through diet or supplements, adding more postbiotics into daily life could be a smart move.
Gut health isn’t just about avoiding discomfort. It’s tied to mood, immunity, weight, and more. So next time that yogurt label shouts about its pre pro and postbiotics, maybe take a second look. It could be onto something.